OBJECTIVE: To determine the effect of chemotherapy on
patients who wished to conceive after successful treatment of
gestational trophoblastic disease. Patients-During a 12-year
period (1984-1995), 90 patients with gestational trophoblastic
tumor at Jordan University Hospital received repeated courses of
chemotherapy; 85 patients are in continued remission (42
invasive mole and 43 choriocarcinoma). Fifty-five patients
wished to conceive. Main outcome measures-Pregnancy, live
births.
RESULTS: Forty-two patients (76%) achieved pregnancy,
resulting in 20 pregnancies and 94 viable babies.
CONCLUSIONS: Chemotherapy is very effective in the cure
of gestational trophoblastic tumors. Return of fertility
compares favorably with the general population of the same
reproductive age. There appears to be no increase in fetal
congenital malformations.
Institution
Department of Obstetrics and Gynecology, Jordan University
Hospital, Amman. |